首页 > 重组蛋白 > Human WASF2 Recombinant Protein

WASF2 (基因名), Wiskott-Aldrich syndrome protein family member 2 (蛋白名), wasf2_human.

产品名称:

Human WASF2/ Wiskott-Aldrich syndrome protein family member 2 Recombinant Protein

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

Protein WAVE-2, Verprolin homology domain-containing protein 2, WASP family protein member 2, WAVE2

序列号:

Q9Y6W5

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

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Human WASF2 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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基因位点

Cytogenetic band: 1p36.11 by HGNC 1p36.11 by Entrez Gene 1p36.11 by Ensembl

WASF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 (NCKAP1l/HEM1 in hematopoietic cells) and WASF2/WAVE2 (PubMed:16417406). Directly interacts with BRK1. Interacts with human cytomegalovirus protein UL135. Interacts with FNBP1L (via the SH3 domain) (PubMed:19798448).

功能:

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.

亚细胞位置:

Cytoplasm Cytoskeleton Cell projection Lamellipodium At the interface between the lamellipodial actin meshwork and the membrane.

数据库链接

UniGene:

Hs.469244

SMR:

Q9Y6W5

STRING:

9606.ENSP00000396211

KEGG:

hsa:10163

MIM:

605875

Pfam:

PF02205

Uniprot:

Q9Y6W5

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序列长度:

498

序列:

仅供参考，详细请咨询（services@eiaab.com）

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498:

RRVEEQREQE | KRDVVGNDVA | TILSRRIAVE | YSDSEDDSSE | FDEDDWSD

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex."

(PMID: 10381382)

[2].

"Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis."

(PMID: 16417406)

[3].

"Structure and control of the actin regulatory WAVE complex."

(PMID: 21107423)

[4].

"Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis."

(PMID: 19798448)

[5].

"The DNA sequence and biological annotation of human chromosome 1."

(PMID: 16710414)

[6].

"Increased expression of Wiskott-Aldrich syndrome protein family verprolin-homologous protein 2 correlated with poor prognosis of hepatocellular carcinoma."

(PMID: 17020969)

[7].

"Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin."

(PMID: 16483316)

[8].

"WAVE/Scars in platelets."

(PMID: 15280206)

[9].

"Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation."

(PMID: 15657136)

[10].

"Abi1 is essential for the formation and activation of a WAVE2 signalling complex."

(PMID: 15048123)

[1].

人WASF2重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人WASF2重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人WASF2重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人WASF2重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人WASF2重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人WASF2重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人WASF2重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人WASF2重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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