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Wnt5a (基因名), Protein Wnt-5a (蛋白名), wnt5a_mouse.
产品名称:

Mouse Wnt5a/ Protein Wnt-5a Recombinant Protein
Wnt-5a蛋白

货号:

R1038m

商标:
EIAab®
监管等级:
别名:

Wnt-5a

序列号:
P22725
来源:
E.coli
种属:
Mouse
标签:
His
序列:
107-228aa
预估分子量:
13.42 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Mouse Wnt5a Protein
规格 & 价格: cart
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Mouse Wnt5a Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Mouse Wnt5a Protein
Recombinant mouse Wnt5a protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
通用注释


亚单元:
Homooligomer; disulfide-linked, leading to inactivation. Interacts with PORCN. Interacts with WLS.


功能:
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.


亚细胞位置:
Secreted Extracellular space Extracellular matrix


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