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ZBP1 (基因名), Z-DNA-binding protein 1 (蛋白名), zbp1_human.
产品名称:

Human ZBP1/ Z-DNA-binding protein 1 Recombinant Protein

货号:

R9277h

商标:
EIAab®
监管等级:
别名:

Tumor stroma and activated macrophage protein DLM-1, C20orf183, DLM1

序列号:
Q9H171
来源:
E.coli
种属:
Human
标签:
His
序列:
1-429aa
预估分子量:
47.19 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human ZBP1 Protein
规格 & 价格: cart
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Human ZBP1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human ZBP1 Protein
Recombinant human ZBP1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 20q13.31 by HGNC 20q13.31 by Entrez Gene 20q13.31 by Ensembl
ZBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3.


亚细胞位置:
N/A


该产品尚未在任何出版物中被引用。

[1].
"Complex regulation of the human gene for the Z-DNA binding protein DLM-1."

[2].
"The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA."

[3].
"Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1."

[4].
"Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease."

[5].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[7].
"Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins."

[8].
"The DNA sequence and comparative analysis of human chromosome 20."

[9].
"PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors."

[10].
"ZBP1: Innate Sensor Regulating Cell Death and Inflammation."
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