首页 > 重组蛋白 > Human AICDA Recombinant Protein

AICDA (基因名), Single-stranded DNA cytosine deaminase (蛋白名), aicda_human.

产品名称:

Human AICDA/ Single-stranded DNA cytosine deaminase Recombinant Protein
活化诱导胞嘧啶核苷脱氨酶

货号:

R14184h

商标:

EIAab^®

监管等级:

RUO

别名:

Activation-induced cytidine deaminase, Cytidine aminohydrolase, AID, AID

序列号:

Q9GZX7

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Epigenetics

规格 & 价格:

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Human AICDA Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 12p13.31 by HGNC 12p13.31 by Entrez Gene 12p13.31 by Ensembl

AICDA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with CTNNBL1; the interaction is important for the immunoglobulin switch activity of AICDA. Interacts (via its NLS) with KPNA1. Interacts with PKA/PRKACA and PRKAR1A/PKR1. Interacts with TRIM28 and NCL (By similarity). Interacts with SUPT6H. Interacts with RNF126.

功能:

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).

亚细胞位置:

Nucleus Cytoplasm Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm.

数据库链接

UniGene:

Hs.149342

SMR:

Q9GZX7

STRING:

9606.ENSP00000229335

KEGG:

hsa:57379

MIM:

605257

Pfam:

PF08210

Uniprot:

Q9GZX7

相关产品

Mouse Aicda ELISA Kit

Bovine AICDA ELISA Kit

Dog AICDA ELISA Kit

Mouse Aicda CLIA Kit

Bovine AICDA CLIA Kit

序列长度:

198

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

198:

FVENHERTFK | AWEGLHENSV | RLSRQLRRIL | LPLYEVDDLR | DAFRTLGL

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels."

(PMID: 11544457)

[2].

"No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese."

(PMID: 20373075)

[3].

"Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1."

(PMID: 18722174)

[4].

"Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1."

(PMID: 14769937)

[5].

"Polymorphisms of IL-4, IL-4R alpha, and AICDA genes in adult allergic asthma."

(PMID: 12973929)

[6].

"Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene."

(PMID: 10950930)

[7].

"Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)."

(PMID: 11007475)

[8].

"Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification."

(PMID: 27258794)

[9].

"Activation induced cytidine deaminase mutant (AID-His130Pro) from Hyper IgM 2 patient retained mutagenic activity on SHM artificial substrate."

(PMID: 27716525)

[10].

"Novel and recurrent AID mutations underlie prevalent autosomal recessive form of HIGM in consanguineous patients."

(PMID: 26545377)

[1].

人活化诱导胞嘧啶核苷脱氨酶(AICDA)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人活化诱导胞嘧啶核苷脱氨酶(AICDA)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人活化诱导胞嘧啶核苷脱氨酶(AICDA)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人活化诱导胞嘧啶核苷脱氨酶(AICDA)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人活化诱导胞嘧啶核苷脱氨酶(AICDA)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人活化诱导胞嘧啶核苷脱氨酶(AICDA)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人活化诱导胞嘧啶核苷脱氨酶(AICDA)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人活化诱导胞嘧啶核苷脱氨酶(AICDA)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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