首页 > 重组蛋白 > Human AIMP1 Recombinant Protein

AIMP1 (基因名), Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (蛋白名), aimp1_human.

产品名称:

Human AIMP1/ Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 Recombinant Protein
氨酰-tRNA合成酶复合体相互作用多功能蛋白1

货号:

R2214h

商标:

EIAab^®

监管等级:

RUO

别名:

Multisynthase complex auxiliary component p43, EMAP2, SCYE1

序列号:

Q12904

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Immunology

规格 & 价格:

关注

Human AIMP1 Protein

邮箱 *

消息 *

Please 登录.

产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
反馈墙 (0)

R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 4q24 by HGNC 4q24 by Entrez Gene 4q24 by Ensembl

AIMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homodimer. Component of the multisynthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts (via N-terminus) with RARS (via N-terminus). Interacts (via C-terminus) with SMURF2. Interacts (via N-terminus) with HSP90B1/gp96 (via C-terminus). Interacts with PSMA7.

功能:

Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.

亚细胞位置:

Nucleus Cytoplasm Cytosol Cytoplasmic vesicle Secretory vesicle Secreted Endoplasmic reticulum Golgi apparatus Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death.

数据库链接

UniGene:

Hs.591680

SMR:

Q12904

STRING:

9606.ENSP00000378191

KEGG:

hsa:9255

MIM:

260600

Pfam:

PF01588

Uniprot:

Q12904

相关产品

Mouse Aimp1 ELISA Kit

Mouse Aimp1 CLIA Kit

Mouse Aimp1 Protein

Mouse Aimp1 Polyclonal Antibody

Mouse Aimp1 Monoclonal Antibody

序列长度:

312

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

312:

CRAQTMSNSG | IK

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome."

(PMID: 19362550)

[2].

"Proteasomes and RARS modulate AIMP1/EMAP II secretion in human cancer cell lines."

(PMID: 17443684)

[3].

"Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II."

(PMID: 7929199)

[4].

"Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for mammalian translation."

(PMID: 25288775)

[5].

"Pelizaeus-Merzbacher-like disease caused by AIMP1/p43 homozygous mutation."

(PMID: 21092922)

[6].

"A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts."

(PMID: 20332099)

[7].

"Dissection of the structural organization of the aminoacyl-tRNA synthetase complex."

(PMID: 19131329)

[8].

"Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells."

(PMID: 19289464)

[9].

"The significance of EMAP-II after allogeneic stem cell transplantation."

(PMID: 19565673)

[10].

"Intratumoural expression of TNF-R1 and EMAP-II in relation to response of patients treated with TNF-based isolated limb perfusion."

(PMID: 16615114)

[1].

人氨酰-tRNA合成酶复合体相互作用多功能蛋白1(AIMP1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人氨酰-tRNA合成酶复合体相互作用多功能蛋白1(AIMP1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人氨酰-tRNA合成酶复合体相互作用多功能蛋白1(AIMP1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人氨酰-tRNA合成酶复合体相互作用多功能蛋白1(AIMP1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人氨酰-tRNA合成酶复合体相互作用多功能蛋白1(AIMP1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人氨酰-tRNA合成酶复合体相互作用多功能蛋白1(AIMP1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人氨酰-tRNA合成酶复合体相互作用多功能蛋白1(AIMP1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人氨酰-tRNA合成酶复合体相互作用多功能蛋白1(AIMP1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

反馈墙

评论数 : 0

所有用户