首页 > 重组蛋白 > Human ASPN Recombinant Protein

ASPN (基因名), Asporin (蛋白名), aspn_human.

产品名称:

Human ASPN/ Asporin Recombinant Protein
Asporin

货号:

R1043h

商标:

EIAab^®

监管等级:

RUO

别名:

Periodontal ligament-associated protein 1, PLAP-1, UNQ215/PRO241, PLAP1, SLRR1C

序列号:

Q9BXN1

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Metabolism

规格 & 价格:

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Human ASPN Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 9q22.31 by HGNC 9q22.31 by Entrez Gene 9q22.31 by Ensembl

ASPN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with TGFB1, TGFB2 and TGFB3. DCN, BGN, and FMOD inhibit binding to TGFB1. Interacts with BMP2. Interacts in vitro with type II collagen (By similarity). Interacts with type I collagen. DCN can inhibit collagen binding.

功能:

Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.

亚细胞位置:

Secreted Extracellular space Extracellular matrix

数据库链接

UniGene:

Hs.435655

SMR:

Q9BXN1

STRING:

9606.ENSP00000364694

KEGG:

hsa:54829

MIM:

603932

Pfam:

PF13855

Uniprot:

Q9BXN1

相关产品

Mouse Aspn ELISA Kit

Bovine ASPN ELISA Kit

Mouse Aspn CLIA Kit

Bovine ASPN CLIA Kit

Mouse Aspn Protein

序列长度:

380

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

350:

380:

NNPVKYWEMQ | PATFRCVLSR | MSVQLGNFGM |

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Association of the asporin D14 allele with lumbar-disc degeneration in Asians."

(PMID: 18304494)

[2].

"Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan."

(PMID: 11152692)

[3].

"Association of an asporin repeat polymorphism with ankylosing spondylitis in Han Chinese population: a case-control study."

(PMID: 20144272)

[4].

"Aspartic acid repeat polymorphism of the asporin gene with susceptibility to osteoarthritis of the knee in a Korean population."

(PMID: 18178444)

[5].

"Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians."

(PMID: 18434216)

[6].

"Association of the CALM1 core promoter polymorphism with knee osteoarthritis in patients of Greek origin."

(PMID: 18452398)

[7].

"Asporin repeat polymorphism in rheumatoid arthritis."

(PMID: 16707531)

[8].

"Mechanisms for asporin function and regulation in articular cartilage."

(PMID: 17827158)

[9].

"Meta-analysis of association between the ASPN D-repeat and osteoarthritis."

(PMID: 17517696)

[10].

"Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population."

(PMID: 17603749)

[1].

人Asporin(ASPN)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人Asporin(ASPN)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人Asporin(ASPN)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人Asporin(ASPN)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人Asporin(ASPN)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人Asporin(ASPN)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人Asporin(ASPN)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人Asporin(ASPN)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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