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首页  >  重组蛋白  >  Human ADAMTS4 Recombinant Protein
ADAMTS4 (基因名), A disintegrin and metalloproteinase with thrombospondin motifs 4 (蛋白名), ats4_human.
产品名称:

Human ADAMTS4/ A disintegrin and metalloproteinase with thrombospondin motifs 4 Recombinant Protein
金属肽酶含血小板反应蛋白基元4

货号:

R1804h

商标:
EIAab®
监管等级:
别名:

ADMP-1, Aggrecanase-1, UNQ769/PRO1563, ADAM-TS 4, KIAA0688

序列号:
O75173
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cell Biology
Human ADAMTS4 Protein
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Human ADAMTS4 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 1q23.3 by HGNC 1q23.3 by Entrez Gene 1q23.3 by Ensembl
ADAMTS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with SRPX2.


功能:
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.


亚细胞位置:
Secreted Extracellular space Extracellular matrix



[1].
"An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients."

[2].
"The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage."

[3].
"Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins."

[4].
"ADAMTS-4_v1 is a splice variant of ADAMTS-4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain."

[5].
"ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes."

[6].
"Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence."

[7].
"Adaptor proteins and Ras synergistically regulate IL-1-induced ADAMTS-4 expression in human chondrocytes."

[8].
"Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation."

[9].
"The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells."

[10].
"Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations."
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