首页 > 重组蛋白 > Human BAX Recombinant Protein

BAX (基因名), Apoptosis regulator BAX (蛋白名), bax_human.

产品名称:

Human BAX/ Apoptosis regulator BAX Recombinant Protein
Bovine细胞凋亡调整器BAX

货号:

R1343h

商标:

EIAab^®

监管等级:

RUO

别名:

Bcl-2-like protein 4, Bcl2-L-4, BCL2L4

序列号:

Q07812

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Neurosciences

规格 & 价格:

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Human BAX Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 19q13.33 by HGNC 19q13.33 by Entrez Gene 19q13.33 by Ensembl

BAX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homodimer. Forms higher oligomers under stress conditions. Interacts with BCL2L11. Interaction with BCL2L11 promotes BAX oligomerization and association with mitochondrial membranes, with subsequent release of cytochrome c. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), BCL2L2, MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Interacts with CLU under stress conditions that cause a conformation change leading to BAX oligomerization and association with mitochondria. Does not interact with CLU in unstressed cells. Interacts with FAIM2/LFG2. Interacts with human cytomegalovirus/HHV-5 protein vMIA/UL37. Interacts with BOP/C22orf29. Interacts (via a C-terminal 33 residues) with NOL3 (via CARD domain); inhibits BAX activation and translocation and consequently cytochrome c release from mitochondria.

功能:

Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

亚细胞位置:

Isoform Delta Cytoplasm

数据库链接

UniGene:

Hs.624291

SMR:

Q07812

STRING:

9606.ENSP00000293288

KEGG:

hsa:581

MIM:

600040

Pfam:

PF00452

Uniprot:

Q07812

相关产品

序列长度:

192

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

192:

WIQDQGGWDG | LLSYFGTPTW | QTVTIFVAGV | LTASLTIWKK | MG

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation."

(PMID: 20300062)

[2].

"Humanin peptide suppresses apoptosis by interfering with Bax activation."

(PMID: 12732850)

[3].

"Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death."

(PMID: 8358790)

[4].

"PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer."

(PMID: 29531808)

[5].

"Human Bop is a novel BH3-only member of the Bcl-2 protein family."

(PMID: 23055042)

[6].

"Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis."

(PMID: 21199865)

[7].

"Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol."

(PMID: 21458670)

[8].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[9].

"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."

(PMID: 20877624)

[10].

"Genetic susceptibility to distinct bladder cancer subphenotypes."

(PMID: 19692168)

[1].

人Bovine细胞凋亡调整器BAX(BAX)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人Bovine细胞凋亡调整器BAX(BAX)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人Bovine细胞凋亡调整器BAX(BAX)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人Bovine细胞凋亡调整器BAX(BAX)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人Bovine细胞凋亡调整器BAX(BAX)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人Bovine细胞凋亡调整器BAX(BAX)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人Bovine细胞凋亡调整器BAX(BAX)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人Bovine细胞凋亡调整器BAX(BAX)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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