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BCL3 (基因名), B-cell lymphoma 3 protein (蛋白名), bcl3_human.
产品名称:

Human BCL3/ B-cell lymphoma 3 protein Recombinant Protein
B细胞淋巴瘤蛋白3

货号:

R1734h

商标:
EIAab®
监管等级:
别名:

Proto-oncogene BCL3, BCL-3, BCL4, D19S37

序列号:
P20749
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human BCL3 Protein
规格 & 价格: cart
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Human BCL3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 19q13.32 by HGNC 19q13.32 by Entrez Gene 19q13.32 by Ensembl
BCL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR. Interacts with CYLD.


功能:
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation.


亚细胞位置:
Nucleus Cytoplasm Cytoplasm Perinuclear region Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.


该产品尚未在任何出版物中被引用。

[1].
"The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control."

[2].
"GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity."

[3].
"Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family."

[4].
"Genomic structure of the candidate proto-oncogene BCL3."

[5].
"The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers."

[6].
"The transcriptional specificity of NF-κB dimers is coded within the κB DNA response elements."

[7].
"CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin."

[8].
"Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappaB activity."

[9].
"MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate."

[10].
"Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease."
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