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BMP1 (基因名), Bone morphogenetic protein 1 (蛋白名), bmp1_human.
产品名称:

Human BMP1/ Bone morphogenetic protein 1 Recombinant Protein
骨形成蛋白1

货号:

R1316h

商标:
EIAab®
监管等级:
别名:

Mammalian tolloid protein, Procollagen C-proteinase, mTld, PCP, BMP-1, PCOLC

序列号:
P13497
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Signal Transduction
Human BMP1 Protein
规格 & 价格: cart
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Human BMP1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 8p21.3 by HGNC 8p21.3 by Entrez Gene 8p21.3 by Ensembl
BMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with POSTN, the interaction promotes deposition on the extracellular matrix.


功能:
Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.


亚细胞位置:
Golgi apparatus Trans-Golgi network Secreted Extracellular space Extracellular matrix Co-localizes with POSTN in the Golgi.


该产品尚未在任何出版物中被引用。

[1].
"Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases."

[2].
"Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network."

[3].
"Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity."

[4].
"The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1."

[5].
"Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues."

[6].
"Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3."

[7].
"Identification and in vivo functional characterization of novel compound heterozygous BMP1 variants in osteogenesis imperfecta."

[8].
"Identification of a mutation causing deficient BMP1/mTLD proteolytic activity in autosomal recessive osteogenesis imperfecta."

[9].
"Attenuated BMP1 function compromises osteogenesis, leading to bone fragility in humans and zebrafish."

[10].
"Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"."
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