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BMPR2 (基因名), Bone morphogenetic protein receptor type-2 (蛋白名), bmpr2_human.
产品名称:

Human BMPR2/ Bone morphogenetic protein receptor type-2 Recombinant Protein
BMPtype-2receptor

货号:

R0016h

商标:
EIAab®
监管等级:
别名:

Bone morphogenetic protein receptor type II, BMP type II receptor, BMP type-2 receptor, PPH1

序列号:
Q13873
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human BMPR2 Protein
规格 & 价格: cart
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Human BMPR2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 2q33.1-q33.2 by HGNC 2q33.1-q33.2 by Entrez Gene 2q33.1-q33.2 by Ensembl
BMPR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with GDF5.


功能:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.


亚细胞位置:
Cell membrane Single-pass type I membrane protein


该产品尚未在任何出版物中被引用。

[1].
"BMPR2 mutations have short lifetime expectancy in primary pulmonary hypertension."

[2].
"BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives."

[3].
"Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs."

[4].
"[Study of the BMPR2 gene in patients with pulmonary arterial hypertension]."

[5].
"Sequence variants in BMPR2 and genes involved in the serotonin and nitric oxide pathways in idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: relation to clinical parameters and comparison with left heart disease."
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