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IDE (基因名), Insulin-degrading enzyme (蛋白名), ide_human.
产品名称:

Human IDE/ Insulin-degrading enzyme Recombinant Protein
胰岛素降解

货号:

R1897h

商标:
EIAab®
监管等级:
别名:

Abeta-degrading protease, Insulin protease, Insulysin, Insulinase

序列号:
P14735
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human IDE Protein
规格 & 价格: cart
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Human IDE Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 10q23.33 by HGNC 10q23.33 by Entrez Gene 10q23.33 by Ensembl
IDE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
(Microbial infection) Interacts (via N-terminus) with varicella-zoster virus (VZV) envelope glycoprotein E (via N-terminus); the membrane-associated isoform may function as an entry receptor for this virus (PubMed:17055432, PubMed:17553876).


功能:
(Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV).


亚细胞位置:
Cytoplasm Cell membrane Secreted Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.


该产品尚未在任何出版物中被引用。

[1].
"Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes."

[2].
"Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease."

[3].
"Combined risk effects of IDE and NEP gene variants on Alzheimer disease."

[4].
"Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes."

[5].
"Variants in the insulin-degrading enzyme gene are associated with metabolic syndrome in Chinese elders."

[6].
"Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease."

[7].
"Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme."

[8].
"Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE."

[9].
"Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures."

[10].
"Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE."
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