首页 > 重组蛋白 > Human EBI3 Recombinant Protein

EBI3 (基因名), Interleukin-27 subunit beta (蛋白名), il27b_human.

产品名称:

Human EBI3/ Interleukin-27 subunit beta Recombinant Protein
白细胞介素-27β亚基

货号:

R9188h

商标:

EIAab^®

监管等级:

RUO

别名:

Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, IL-27 subunit beta, IL27B

序列号:

Q14213

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human EBI3 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 19p13.3 by HGNC 19p13.3 by Entrez Gene 19p13.3 by Ensembl

EBI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Heterodimer with IL27/IL27A; not disulfide-linked. This heterodimer is known as interleukin IL-27. EBI3 is also a component of the IL-12 heterodimer. Interacts with SQSTM1. Heterodimer with IL12A; this heterodimer is known as interleukin IL-35.

功能:

Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.

亚细胞位置:

Secreted

数据库链接

UniGene:

Hs.501452

STRING:

9606.ENSP00000221847

KEGG:

hsa:10148

MIM:

605816

Pfam:

PF00041

Uniprot:

Q14213

相关产品

Mouse Ebi3 ELISA Kit

Mouse Ebi3 CLIA Kit

Mouse Ebi3 Protein

Mouse Ebi3 Polyclonal Antibody

Mouse Ebi3 Monoclonal Antibody

序列长度:

229

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

229:

VQVAAQDLTD | YGELSDWSLP | ATATMSLGK

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin."

(PMID: 9342359)

[2].

"A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes."

(PMID: 8551575)

[3].

"Epstein-barr virus-induced gene-3 is expressed in human atheroma plaques."

(PMID: 19556516)

[4].

"Enhanced expression of IL-27 mRNA in human newborns."

(PMID: 18167155)

[5].

"Genome-wide analysis displays marked induction of EBI3/IL-27B in IL-18-activated AML-derived KG1 cells: critical role of two kappaB binding sites in the human EBI3 promotor."

(PMID: 18336908)

[6].

"IL27: its roles in the induction and inhibition of inflammation."

(PMID: 18784808)

[7].

"The DNA sequence and biology of human chromosome 19."

(PMID: 15057824)

[8].

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

(PMID: 15489334)

[9].

"Expression of IL-27 in human Th1-associated granulomatous diseases."

(PMID: 14743498)

[10].

"Epstein-Barr virus (EBV) infection and expression of the interleukin-12 family member EBV-induced gene 3 (EBI3) in chronic inflammatory bowel disease."

(PMID: 15170639)

[1].

人白细胞介素-27β亚基(EBI3)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人白细胞介素-27β亚基(EBI3)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人白细胞介素-27β亚基(EBI3)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人白细胞介素-27β亚基(EBI3)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人白细胞介素-27β亚基(EBI3)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人白细胞介素-27β亚基(EBI3)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人白细胞介素-27β亚基(EBI3)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人白细胞介素-27β亚基(EBI3)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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