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IL4R (基因名), Interleukin-4 receptor subunit alpha (蛋白名), il4ra_human.
产品名称:

Human IL4R/ Interleukin-4 receptor subunit alpha Recombinant Protein
白介素4受体α亚基

货号:

R2031h

商标:
EIAab®
监管等级:
别名:

CD124, 582J2.1, IL-4 receptor subunit alpha, IL4RA

序列号:
P24394
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Human IL4R Protein
规格 & 价格: cart
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Human IL4R Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 16p12.1 by HGNC 16p12.1 by Entrez Gene 16p12.1 by Ensembl
IL4R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor (PubMed:7775445, PubMed:8804422). Interacts with PIK3C3 (By similarity). Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (PubMed:11714803). Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling (By similarity). Interacts with JAK3 (PubMed:7538655). Interacts with CLM1.


功能:
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.


亚细胞位置:
Isoform 2 Secreted


该产品尚未在任何出版物中被引用。

[1].
"The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor."

[2].
"Analysis of polymorphisms in olive pollen allergy: IL13, IL4RA, IL5 and ADRB2 genes."

[3].
"Genetic variants in immunoregulatory genes and risk for childhood lymphomas."

[4].
"Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial."

[5].
"Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era."

[6].
"Interleukin promoter polymorphisms and prognosis in colorectal cancer."

[7].
"Clinical and genetic risk factors of self-reported penicillin allergy."

[8].
"Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children."

[9].
"Frequency distribution of cytokine gene polymorphisms in the healthy North Indian population."

[10].
"Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma."
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