首页 > 重组蛋白 > Human IL6ST Recombinant Protein

IL6ST (基因名), Interleukin-6 receptor subunit beta (蛋白名), il6rb_human.

产品名称:

Human IL6ST/ Interleukin-6 receptor subunit beta Recombinant Protein
白介素6受体β亚基

货号:

R0046h

商标:

EIAab^®

监管等级:

RUO

别名:

CDw130, Interleukin-6 signal transducer, Membrane glycoprotein 130, Oncostatin-M receptor subunit alpha, gp130, CD130, IL-6 receptor subunit beta

序列号:

P40189

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cancer

规格 & 价格:

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Human IL6ST Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 1 )
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 5q11.2 by HGNC 5q11.2 by Entrez Gene 5q11.2 by Ensembl

IL6ST Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Component of a hexamer of two molecules each of IL6, IL6R and IL6ST (PubMed:12829785). Forms heterodimers composed of LIFR and IL6ST (type I OSM receptor) which are activated by LIF and OSM (PubMed:8999038). Also forms heterodimers composed of OSMR and IL6ST (type II receptor) which are activated by OSM but not by LIF (PubMed:8999038). Homodimer. The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6 (PubMed:11238858, PubMed:11251120). Interacts with HCK (PubMed:9406996). Interacts with INPP5D/SHIP1.

功能:

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition.

亚细胞位置:

Isoform 2 Secreted

数据库链接

UniGene:

Hs.532082

SMR:

P40189

STRING:

9606.ENSP00000338799

KEGG:

hsa:3572

MIM:

600694

Pfam:

PF00041

Uniprot:

P40189

相关产品

Mouse Il6st ELISA Kit

序列长度:

918

序列:

仅供参考，详细请咨询（services@eiaab.com）

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918:

MPKSYLPQTV | RQGGYMPQ

3D 模型:

3D 结构:

免疫原序列:

验证序列:

[1].

"Is Chronic Curcumin Supplementation Neuroprotective Against Ischemia for Antioxidant Activity, Neurological Deficit, or Neuronal Apoptosis in an..."

ALTINAY S, CABALAR M, ISLER C, et al.

From: Turk Neurosurg

[1].

"Molecular cloning and expression of an IL-6 signal transducer, gp130."

(PMID: 2261637)

[2].

"N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130."

(PMID: 19915009)

[3].

"Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling."

(PMID: 11238858)

[4].

"Structure of an extracellular gp130 cytokine receptor signaling complex."

(PMID: 11251120)

[5].

"Phosphorylation of human gp130 at Ser-782 adjacent to the Di-leucine internalization motif. Effects on expression and signaling."

(PMID: 10811661)

[6].

"Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis."

(PMID: 10880057)

[7].

"Low incidence of IL6ST (gp130) mutations in exon 6 in lung cancer of a Chinese cohort."

(PMID: 25242236)

[8].

"Glycoprotein 130 polymorphism predicts soluble glycoprotein 130 levels."

(PMID: 24629561)

[9].

"gp130 activation is regulated by D2-D3 interdomain connectivity."

(PMID: 23294003)

[10].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[1].

人白介素6受体β亚基(IL6ST)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人白介素6受体β亚基(IL6ST)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人白介素6受体β亚基(IL6ST)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人白介素6受体β亚基(IL6ST)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人白介素6受体β亚基(IL6ST)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人白介素6受体β亚基(IL6ST)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人白介素6受体β亚基(IL6ST)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人白介素6受体β亚基(IL6ST)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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