首页 > 重组蛋白 > Human INAVA Recombinant Protein

INAVA (基因名), Innate immunity activator protein (蛋白名), inava_human.

产品名称:

Human INAVA/ Innate immunity activator protein Recombinant Protein
不典型蛋白C1orf106

货号:

R4998h

商标:

EIAab^®

监管等级:

RUO

别名:

C1orf106

序列号:

Q3KP66

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human INAVA Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 1q32.1 by HGNC 1q32.1 by Entrez Gene 1q32.1 by Ensembl

INAVA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with IRAK1, NOD2 and RIPK2; the interaction takes place upon PRR stimulation (PubMed:28436939). Interacts with YWHAQ/14-3-3T; the interaction increases upon PRR stimulation and is required for cellular signaling pathway activation and cytokine secretion (PubMed:28436939). Interacts (via N-terminal domain) with CYTH1 and CYTH2 (via their N-terminal domains) (PubMed:29420262). Interacts with FBXW11 and BTRC; associates with SCF E3 ubiquitin-protein ligase complexes (PubMed:29420262).

功能:

Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).

亚细胞位置:

Nucleus Cytoplasm Translocates to the nucleus upon NOD2 stimulation.

数据库链接

UniGene:

Hs.518997

STRING:

9606.ENSP00000356311

KEGG:

hsa:55765

Pfam:

PF11819

Uniprot:

Q3KP66

相关产品

Human INAVA ELISA Kit

Human INAVA CLIA Kit

Human INAVA Polyclonal Antibody

Human INAVA Monoclonal Antibody

Human INAVA

序列长度:

663

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

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674:

RRSPDGAPVQ | VFVPEKGEII | SQV

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions."

(PMID: 29420262)

[2].

"An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes."

(PMID: 28436939)

[3].

"Complete sequencing and characterization of 21,243 full-length human cDNAs."

(PMID: 14702039)

[4].

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

(PMID: 15489334)

[5].

"Architecture of the human interactome defines protein communities and disease networks."

(PMID: 28514442)

[6].

"Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis."

(PMID: 27980695)

[7].

"A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis."

(PMID: 25082827)

[8].

"E-cadherin interactome complexity and robustness resolved by quantitative proteomics."

(PMID: 25468996)

[9].

"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease."

(PMID: 23128233)

[10].

"Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47."

(PMID: 21297633)

[1].

人不典型蛋白C1orf106(INAVA)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人不典型蛋白C1orf106(INAVA)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人不典型蛋白C1orf106(INAVA)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人不典型蛋白C1orf106(INAVA)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人不典型蛋白C1orf106(INAVA)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人不典型蛋白C1orf106(INAVA)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人不典型蛋白C1orf106(INAVA)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人不典型蛋白C1orf106(INAVA)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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