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SPINK1 (基因名), Serine protease inhibitor Kazal-type 1 (蛋白名), isk1_human.
产品名称:

Human SPINK1/ Serine protease inhibitor Kazal-type 1 Recombinant Protein
分泌型胰蛋白酶抑制物

货号:

R1420h

商标:
EIAab®
监管等级:
别名:

Pancreatic secretory trypsin inhibitor, Tumor-associated trypsin inhibitor, TATI, PSTI

序列号:
P00995
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human SPINK1 Protein
规格 & 价格: cart
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Human SPINK1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 5q32 by HGNC 5q32 by Entrez Gene 5q32 by Ensembl
SPINK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.


亚细胞位置:
Secreted



[1].
"SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event."

[2].
"Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis."

[3].
"Connections between genetics and clinical data: Role of MCP-1, CFTR, and SPINK-1 in the setting of acute, acute recurrent, and chronic pancreatitis."

[4].
"Common SPINK-1 mutations do not predispose to the development of non-alcoholic fatty liver disease."

[5].
"Investigation of the SPINK1 N34S mutation in Romanian patients with alcoholic chronic pancreatitis. A clinical analysis based on the criteria of the M-ANNHEIM classification."

[6].
"The SPINK1 N34S variant is associated with acute pancreatitis."

[7].
"SPINK1, ADH2, and ALDH2 gene variants and alcoholic chronic pancreatitis in Japan."

[8].
"Pancreatitis risk in primary hyperparathyroidism: relation to mutations in the SPINK1 trypsin inhibitor (N34S) and the cystic fibrosis gene."

[9].
"Clinical and radiological outcome of patients suffering from chronic pancreatitis associated with gene mutations."

[10].
"SPINK1 and PRSS1 mutations in benign pancreatic hyperenzymemia."
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