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ITGAM (基因名), Integrin alpha-M (蛋白名), itam_human.
产品名称:

Human ITGAM/ Integrin alpha-M Recombinant Protein
整合素α-M

货号:

R1685h

商标:
EIAab®
监管等级:
别名:

CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD11b, CD11B, CR3A

序列号:
P11215
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human ITGAM Protein
规格 & 价格: cart
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Human ITGAM Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 16p11.2 by HGNC 16p11.2 by Entrez Gene 16p11.2 by Ensembl
ITGAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3 (PubMed:15194813, PubMed:12208882). Interacts with THBD (PubMed:27055590).


功能:
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.


亚细胞位置:
Membrane Single-pass type I membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci."

[2].
"A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus."

[3].
"The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression."

[4].
"CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation."

[5].
"A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles."
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