首页 > 重组蛋白 > Human ITGB2 Recombinant Protein

ITGB2 (基因名), Integrin beta-2 (蛋白名), itb2_human.

产品名称:

Human ITGB2/ Integrin beta-2 Recombinant Protein
整合素beta 2

货号:

R0236h

商标:

EIAab^®

监管等级:

RUO

别名:

Cell surface adhesion glycoproteins LFA-1/CR3/p150, 95 subunit beta, Complement receptor C3 subunit beta, CD18, CD18, MFI7

序列号:

P05107

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cancer

规格 & 价格:

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Human ITGB2 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 21q22.3 by HGNC 21q22.3 by Entrez Gene 21q22.3 by Ensembl

ITGB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Heterodimer of an alpha and a beta subunit (PubMed:20033057). Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with FGR (By similarity). Interacts with COPS5 and RANBP9 (PubMed:10766246, PubMed:14722085). Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23) (PubMed:19828450). Interacts with THBD (PubMed:27055590).

功能:

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).

亚细胞位置:

Membrane Single-pass type I membrane protein

数据库链接

UniGene:

Hs.375957

SMR:

P05107

STRING:

9606.ENSP00000303242

KEGG:

hsa:3689

MIM:

116920

Pfam:

PF08725

Uniprot:

P05107

相关产品

Mouse Itgb2 ELISA Kit

Bovine ITGB2 ELISA Kit

Pig ITGB2 ELISA Kit

Mouse Itgb2 CLIA Kit

Bovine ITGB2 CLIA Kit

序列长度:

769

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

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750:

769:

NPLFKSATTT | VMNPKFAES

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"The ITGB2 immunomodulatory gene (CD18), enterocolitis, and Hirschsprung's disease."

(PMID: 18675632)

[2].

"A prospective evaluation of the CD14 and CD18 gene polymorphisms and risk of stroke."

(PMID: 11935032)

[3].

"A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1."

(PMID: 9884339)

[4].

"Molecular basis for a severe case of leukocyte adhesion deficiency."

(PMID: 1352501)

[5].

"CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation."

(PMID: 28807980)

[6].

"Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation."

(PMID: 21193407)

[7].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[8].

"An approach based on a genome-wide association study reveals candidate loci for narcolepsy."

(PMID: 20677014)

[9].

"Human variation in alcohol response is influenced by variation in neuronal signaling genes."

(PMID: 20201926)

[10].

"Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls."

(PMID: 20503287)

[1].

人整合素beta 2(ITGB2)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人整合素beta 2(ITGB2)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人整合素beta 2(ITGB2)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人整合素beta 2(ITGB2)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人整合素beta 2(ITGB2)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人整合素beta 2(ITGB2)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人整合素beta 2(ITGB2)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人整合素beta 2(ITGB2)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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