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IZUMO1 (基因名), Izumo sperm-egg fusion protein 1 (蛋白名), izum1_human.
产品名称:

Human IZUMO1/ Izumo sperm-egg fusion protein 1 Recombinant Protein
出云精卵融合蛋白1

货号:

R1556h

商标:
EIAab®
监管等级:
别名:

Oocyte binding/fusion factor, Sperm-specific protein izumo, OBF

序列号:
Q8IYV9
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human IZUMO1 Protein
规格 & 价格: cart
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Human IZUMO1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 19q13.33 by HGNC 19q13.33 by Entrez Gene 19q13.33 by Ensembl
IZUMO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Monomer (PubMed:27309818, PubMed:27309808). Monomer, homodimer and homooligomer (By similarity). Interacts with IZUMO1R/JUNO. IZUMO1 and IZUMO1R/JUNO form a complex with 1:1 stoichiometry (PubMed:27309818, PubMed:27309808).


功能:
Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.


亚细胞位置:
Cell membrane Single-pass type I membrane protein


该产品尚未在任何出版物中被引用。

[1].
"The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs."

[2].
"Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure."

[3].
"Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization."

[4].
"Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex."

[5].
"Positive Selection and the Evolution of izumo Genes in Mammals."

[6].
"Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm."

[7].
"Putative sperm fusion protein IZUMO and the role of N-glycosylation."

[8].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[9].
"Architecture of the human interactome defines protein communities and disease networks."

[10].
"Juno is the egg Izumo receptor and is essential for mammalian fertilization."
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