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KIF5A (基因名), Kinesin heavy chain isoform 5A (蛋白名), kif5a_human.
产品名称:

Human KIF5A/ Kinesin heavy chain isoform 5A Recombinant Protein
驱动蛋白重链异构体5A

货号:

R0155h

商标:
EIAab®
监管等级:
别名:

Kinesin heavy chain neuron-specific 1, Neuronal kinesin heavy chain, NKHC, NKHC1

序列号:
Q12840
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human KIF5A Protein
规格 & 价格: cart
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Human KIF5A Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 12q13.3 by HGNC 12q13.3 by Entrez Gene 12q13.3 by Ensembl
KIF5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1. Interacts with FMR1 (via C-terminus); this interaction is increased in a mGluR-dependent manner. Interacts with ZFYVE27. Interacts with VAPA, VAPB, SURF4, RAB11A (GDP-bound form), RAB11B (GDP-bound form) and RTN3 in a ZFYVE27-dependent manner (By similarity). Interacts with BORCS5 (PubMed:25898167). Interacts with BICD2 (PubMed:20386726).


功能:
Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons.


亚细胞位置:
Cytoplasm Perinuclear region Cytoplasm Cytoskeleton Concentrated in the cell body of the neurons, particularly in the perinuclear region.


该产品尚未在任何出版物中被引用。

[1].
"Mutation in KIF5A can also cause adult-onset hereditary spastic paraplegia."

[2].
"Complicated forms of autosomal dominant hereditary spastic paraplegia are frequent in SPG10."

[3].
"Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity."

[4].
"Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia."

[5].
"Assignment of GALGT encoding beta-1, 4N-acetylgalactosaminyl-transferase (GalNAc-T) and KIF5A encoding neuronal kinesin (D12S1889) to human chromosome band 12q13 by assignment to ICI YAC 26EG10 and in situ hybridization. medjph@stjames.leeds.ac.uk."
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