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SSB (基因名), Lupus La protein (蛋白名), la_human.
产品名称:

Human SSB/ Lupus La protein Recombinant Protein
狼疮La蛋白同源物

货号:

R0275h

商标:
EIAab®
监管等级:
别名:

La autoantigen, La ribonucleoprotein, Sjoegren syndrome type B antigen, SS-B

序列号:
P05455
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Epigenetics
Human SSB Protein
规格 & 价格: cart
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Human SSB Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 2q31.1 by HGNC 2q31.1 by Entrez Gene 2q31.1 by Ensembl
SSB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with DDX15. May interact with RUFY1.


功能:
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein."

[2].
"Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding."

[3].
"Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein."

[4].
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."

[5].
"Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen."

[6].
"Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes."

[7].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[8].
"Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein."

[9].
"Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element."

[10].
"Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs."
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