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LAMC2 (基因名), Laminin subunit gamma-2 (蛋白名), lamc2_human.
产品名称:

Human LAMC2/ Laminin subunit gamma-2 Recombinant Protein
层粘连蛋白亚基gamma-2

货号:

R1470h

商标:
EIAab®
监管等级:
别名:

Cell-scattering factor 140 kDa subunit, Epiligrin subunit gamma, Kalinin subunit gamma, Kalinin/nicein/epiligrin 100 kDa subunit, Ladsin 140 kDa subunit, Laminin B2t chain, Laminin-5 subunit gamma, Large adhesive scatter factor 140 kDa subunit, Nicein subunit gamma, CSF 140 kDa subunit, LAMB2T, LAMNB2

序列号:
Q13753
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human LAMC2 Protein
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Human LAMC2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 1q25.3 by HGNC 1q25.3 by Entrez Gene 1q25.3 by Ensembl
LAMC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-2 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein).


功能:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.


亚细胞位置:
Secreted Extracellular space Extracellular matrix Basement membrane Major component.


该产品尚未在任何出版物中被引用。

[1].
"Structure of the human laminin gamma 2 chain gene (LAMC2): alternative splicing with different tissue distribution of two transcripts."

[2].
"Mutations in the gamma 2 chain gene (LAMC2) of kalinin/laminin 5 in the junctional forms of epidermolysis bullosa."

[3].
"The 100-kDa chain of nicein/kalinin is a laminin B2 chain variant."

[4].
"A truncated laminin chain homologous to the B2 chain: structure, spatial expression, and chromosomal assignment."

[5].
"Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project."

[6].
"Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production."

[7].
"Uncoupled responses of Smad4-deficient cancer cells to TNFalpha result in secretion of monomeric laminin-gamma2."

[8].
"Overexpression of malignancy-associated laminins and laminin receptors by angiotropic human melanoma cells in a chick chorioallantoic membrane model."

[9].
"Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells."

[10].
"Profiling bladder cancer organ site-specific metastasis identifies LAMC2 as a novel biomarker of hematogenous dissemination."
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