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LARP7 (基因名), La-related protein 7 (蛋白名), larp7_human.
产品名称:

Human LARP7/ La-related protein 7 Recombinant Protein
La相关蛋白7

货号:

R14792h

商标:
EIAab®
监管等级:
别名:

La ribonucleoprotein domain family member 7, P-TEFb-interaction protein for 7SK stability, PIP7S, HDCMA18P

序列号:
Q4G0J3
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Epigenetics
Human LARP7 Protein
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Human LARP7 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 4q25 by HGNC 4q25 by Entrez Gene 4q25 by Ensembl
LARP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Integral part of the 7SK RNP complex. Specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA. On stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex.


功能:
Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.


亚细胞位置:
Nucleus Nucleoplasm


该产品尚未在任何出版物中被引用。

[1].
"Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism."

[2].
"A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis."

[3].
"LARP7 is a potential tumor suppressor gene in gastric cancer."

[4].
"A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts."

[5].
"Gene expression in early stage cervical cancer."

[6].
"LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated."

[7].
"The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes."

[8].
"LARP7 in papillary thyroid carcinoma induces NIS expression through suppression of the SHH signaling pathway."

[9].
"Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7."

[10].
"Architecture of the human interactome defines protein communities and disease networks."
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