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ALOX5 (基因名), Arachidonate 5-lipoxygenase (蛋白名), lox5_human.
产品名称:

Human ALOX5/ Arachidonate 5-lipoxygenase Recombinant Protein
花生四烯酸5脂加氧

货号:

R1355h

商标:
EIAab®
监管等级:
别名:

5-LO, LOG5

序列号:
P09917
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cardiovascular
Human ALOX5 Protein
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Human ALOX5 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 10q11.21 by HGNC 10q11.21 by Entrez Gene 10q11.21 by Ensembl
ALOX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with ALOX5AP and LTC4S. Interacts with COTL1, the interaction is required for stability and efficient catalytic activity.


功能:
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.


亚细胞位置:
Cytoplasm Nucleus matrix Nucleus membrane Peripheral membrane protein Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.



[1].
"Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export."

[2].
"Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102."

[3].
"5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci."

[4].
"Association studies of ALOX5 and bone mineral density in healthy adults."

[5].
"ALOX5 promoter genotype and response to montelukast in moderate persistent asthma."

[6].
"Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction."

[7].
"Arachidonate 5-lipoxygenase (5-LO) promoter genotype and risk of myocardial infarction: a case-control study."

[8].
"Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast."

[9].
"Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils."

[10].
"ALOX5 promoter genotype, asthma severity and LTC production by eosinophils."
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