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ALOX15B (基因名), Arachidonate 15-lipoxygenase B (蛋白名), lx15b_human.
产品名称:

Human ALOX15B/ Arachidonate 15-lipoxygenase B Recombinant Protein
花生四烯酸15-lipoxygenase B

货号:

R1356h

商标:
EIAab®
监管等级:
别名:

15-lipoxygenase 2, Arachidonate 15-lipoxygenase type II, Linoleate 13-lipoxygenase 15-LOb, 15-LOX-2, 15-LOX-B

序列号:
O15296
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cardiovascular
Human ALOX15B Protein
规格 & 价格: cart
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Human ALOX15B Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 17p13.1 by HGNC 17p13.1 by Entrez Gene 17p13.1 by Ensembl
ALOX15B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.


亚细胞位置:
Cytoplasm Cytosol Cell membrane Cytoplasm Cytoskeleton Membrane Peripheral membrane protein Predominantly cytosolic; becomes enriched at membranes upon calcium binding.


该产品尚未在任何出版物中被引用。

[1].
"Discovery of a second 15S-lipoxygenase in humans."

[2].
"15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration."

[3].
"Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants."

[4].
"Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells."

[5].
"A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression."

[6].
"Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2."

[7].
"Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase."

[8].
"The structure of human 15-lipoxygenase-2 with a substrate mimic."

[9].
"Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis."

[10].
"Risk of meningioma and common variation in genes related to innate immunity."
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