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MADCAM1 (基因名), Mucosal addressin cell adhesion molecule 1 (蛋白名), madca_human.
产品名称:

Human MADCAM1/ Mucosal addressin cell adhesion molecule 1 Recombinant Protein
黏膜地址素细胞黏附分子1

货号:

R1521h

商标:
EIAab®
监管等级:
别名:

MAdCAM-1

序列号:
Q13477
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Human MADCAM1 Protein
规格 & 价格: cart
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Human MADCAM1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 19p13.3 by HGNC 19p13.3 by Entrez Gene 19p13.3 by Ensembl
MADCAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer.


功能:
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.


亚细胞位置:
Membrane Single-pass type I membrane protein



[1].

[1].
"Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene."

[2].
"Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences."

[3].
"Possible impact of MADCAM1 gene single nucleotide polymorphisms to the outcome of allogeneic hematopoietic stem cell transplantation."

[4].
"Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis."

[5].
"A reassessment of the MAdCAM-1 structure and its role in integrin recognition."

[6].
"The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition."

[7].
"Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts."

[8].
"Domain 1 of mucosal addressin cell adhesion molecule has an I1-set fold and a flexible integrin-binding loop."

[9].
"CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow."

[10].
"Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells."
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