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MANF (基因名), Mesencephalic astrocyte-derived neurotrophic factor (蛋白名), manf_human.
产品名称:

Human MANF/ Mesencephalic astrocyte-derived neurotrophic factor Recombinant Protein
中脑星形胶质细胞来源神经营养因子

货号:

R9615h

商标:
EIAab®
监管等级:
别名:

Arginine-rich protein, Protein ARMET, ARMET, ARP

序列号:
P55145
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human MANF Protein
规格 & 价格: cart
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Human MANF Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 3p21.2 by HGNC 3p21.2 by Entrez Gene 3p21.2 by Ensembl
MANF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.


亚细胞位置:
Secreted


该产品尚未在任何出版物中被引用。

[1].
"MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons."

[2].
"Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer."

[3].
"A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas."

[4].
"Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck."

[5].
"MANF: A New Player in the Control of Energy Homeostasis, and Beyond."

[6].
"Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection."

[7].
"The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional."

[8].
"Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death."

[9].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[10].
"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
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