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首页  >  重组蛋白  >  Human SLC11A2 Recombinant Protein
SLC11A2 (基因名), Natural resistance-associated macrophage protein 2 (蛋白名), nram2_human.
产品名称:

Human SLC11A2/ Natural resistance-associated macrophage protein 2 Recombinant Protein
自然抵抗相关的巨噬细胞蛋白2

货号:

R0316h

商标:
EIAab®
监管等级:
别名:

Divalent cation transporter 1, Divalent metal transporter 1, Solute carrier family 11 member 2, DMT-1, OK/SW-cl.20, NRAMP 2, DCT1, DMT1, NRAMP2

序列号:
P49281
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human SLC11A2 Protein
规格 & 价格: cart
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Human SLC11A2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 12q13.12 by HGNC 12q13.12 by Entrez Gene 12q13.12 by Ensembl
SLC11A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Forms a complex with NDFIP1 and NEDD4L, in cortical neurons, in response to iron and colbalt exposure; this interaction leads to ubiquitination by NEDD4L and proteasome-dependent degradation. Interacts with NDFIP2. Interacts with COX2 and TOM6 at the outer mitochondrion membrane.


功能:
Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria.


亚细胞位置:
Endosome membrane Multi-pass membrane protein Mitochondrion outer membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons."

[2].
"Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1)."

[3].
"Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload."

[4].
"Candidate gene association study of solute carrier family 11a members 1 (SLC11A1) and 2 (SLC11A2) genes in Alzheimer's disease."

[5].
"SLC11A1 (NRAMP1) but not SLC11A2 (NRAMP2) polymorphisms are associated with susceptibility to tuberculosis in a high-incidence community in South Africa."
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