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OAS1 (基因名), 2'-5'-oligoadenylate synthase 1 (蛋白名), oas1_human.
产品名称:

Human OAS1/ 2'-5'-oligoadenylate synthase 1 Recombinant Protein
2 5 -oligoadenylate合成酶1

货号:

R0330h

商标:
EIAab®
监管等级:
别名:

E18/E16, p46/p42 OAS, (2-5')oligo(A) synthase 1, OIAS

序列号:
P00973
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human OAS1 Protein
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Human OAS1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 12q24.2 by HGNC 12q24.2 by Entrez Gene 12q24.2 by Ensembl
OAS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Monomer (PubMed:9407111). Homotetramer (PubMed:9407111, PubMed:23319625).


功能:
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.


亚细胞位置:
Cytoplasm Mitochondrion Nucleus Microsome Endoplasmic reticulum Secreted Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.


该产品尚未在任何出版物中被引用。

[1].
"Evolution of the 2'-5'-oligoadenylate synthetase family in eukaryotes and bacteria."

[2].
"Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection."

[3].
"Polymorphism of OAS-1 determines liver fibrosis progression in hepatitis C by reduced ability to inhibit viral replication."

[4].
"Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype?"

[5].
"The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla."
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