首页 > 重组蛋白 > Human PA2G4 Recombinant Protein

PA2G4 (基因名), Proliferation-associated protein 2G4 (蛋白名), pa2g4_human.

产品名称:

Human PA2G4/ Proliferation-associated protein 2G4 Recombinant Protein
增殖相关蛋白2G4

货号:

R1733h

商标:

EIAab^®

监管等级:

RUO

别名:

Cell cycle protein p38-2G4 homolog, ErbB3-binding protein 1, hG4-1, EBP1

序列号:

Q9UQ80

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Epigenetics

规格 & 价格:

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Human PA2G4 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 12q13.2 by HGNC 12q13.2 by Entrez Gene 12q13.2 by Ensembl

PA2G4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Isoform 2 interacts with the cytoplasmic domain of non-phosphorylated ERBB3; the interaction requires PKC activity. Interacts with AR. Treatment with HRG leads to dissociation from ERBB3 and increases association with AR. Interacts with NCL/nucleolin. Component of a ribonucleoprotein complex containing at least PA2G4, NCL, TOP1, PABPC2, RPLP0, acetylated histone H1 (HIST1H1A or H1F1), histone H1 2/4, RPL4, RPL8, RPL15, RPL18, RPL18A, RPL21, RPL11, RPL12, RPL28, RPL27, RPLP2 and RPL24. Interacts with HDAC2. Interacts with RB1; the interaction is enhanced upon PA2G4 dephosphorylation. Interacts with AKT1 (By similarity). Isoform 1 and isoform 2 interact with RNF20. Isoform 2 interacts with HUWE1. Interacts with DNAJC21 (PubMed:27346687).

功能:

May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation.

亚细胞位置:

Isoform 2 Cytoplasm

数据库链接

UniGene:

Hs.524498

SMR:

Q9UQ80

STRING:

9606.ENSP00000302886

KEGG:

hsa:5036

MIM:

602145

Pfam:

PF00557

Uniprot:

Q9UQ80

相关产品

Mouse Pa2g4 ELISA Kit

Mouse Pa2g4 CLIA Kit

Mouse Pa2g4 Protein

Mouse Pa2g4 Polyclonal Antibody

Mouse Pa2g4 Monoclonal Antibody

序列长度:

394

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

350:

394:

DAELKALLQS | SASRKTQKKK | KKKASKTAEN | ATSGETLEEN | EAGD

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4."

(PMID: 9345902)

[2].

"The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions."

(PMID: 17765895)

[3].

"Specificity and heregulin regulation of Ebp1 (ErbB3 binding protein 1) mediated repression of androgen receptor signalling."

(PMID: 15583694)

[4].

"Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases."

(PMID: 12682367)

[5].

"Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation."

(PMID: 11268000)

[6].

"Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin."

(PMID: 10682683)

[7].

"Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor."

(PMID: 19037095)

[8].

"EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance."

(PMID: 18852121)

[9].

"Inhibition of heregulin mediated MCF-7 breast cancer cell growth by the ErbB3 binding protein EBP1."

(PMID: 18355957)

[10].

"Expression, purification, crystallization and preliminary crystallographic analysis of the proliferation-associated protein Ebp1."

(PMID: 17768350)

[1].

人增殖相关蛋白2G4(PA2G4)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人增殖相关蛋白2G4(PA2G4)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人增殖相关蛋白2G4(PA2G4)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人增殖相关蛋白2G4(PA2G4)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人增殖相关蛋白2G4(PA2G4)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人增殖相关蛋白2G4(PA2G4)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人增殖相关蛋白2G4(PA2G4)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人增殖相关蛋白2G4(PA2G4)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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