首页 > 重组蛋白 > Human ACAN Recombinant Protein

ACAN (基因名), Aggrecan core protein (蛋白名), pgca_human.

产品名称:

Human ACAN/ Aggrecan core protein Recombinant Protein
Aggrecan核心蛋白

货号:

R1908h

商标:

EIAab^®

监管等级:

RUO

别名:

Cartilage-specific proteoglycan core protein, Chondroitin sulfate proteoglycan core protein 1, CSPCP, Chondroitin sulfate proteoglycan 1, AGC1, CSPG1, MSK16

序列号:

P16112

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Signal Transduction

规格 & 价格:

关注

Human ACAN Protein

邮箱 *

消息 *

Please 登录.

产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 1 )
出版物
序列 / 3D
常见问题解答
反馈墙 (0)

R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 15q26.1 by HGNC 15q26.1 by Entrez Gene 15q26.1 by Ensembl

ACAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with FBLN1 (By similarity). Interacts with COMP.

功能:

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

亚细胞位置:

Secreted Extracellular space Extracellular matrix

数据库链接

UniGene:

Hs.2159

SMR:

P16112

MIM:

155760

Pfam:

PF00059

Uniprot:

P16112

相关产品

Mouse Acan ELISA Kit

Rat Acan ELISA Kit

Bovine ACAN ELISA Kit

Chicken ACAN ELISA Kit

Pig ACAN ELISA Kit

序列长度:

2415

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1300:

1350:

1400:

1450:

1500:

1550:

1600:

1650:

1700:

1750:

1800:

1850:

1900:

1950:

2000:

2050:

2100:

2150:

2200:

2250:

2300:

2350:

2400:

2415:

RSSRHPRRSR | PSTAH

3D 模型:

3D 结构:

免疫原序列:

验证序列:

[1].

"Overexpression of hTERT extends replicative capacity of human nucleus pulposus cells, and protects against serum starvation-induced apoptosis and..."

W Liang, D Ye, L Dai, et al.

From: Journal of Cellular Biochemistry

[1].

"Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms."

(PMID: 1985970)

[2].

"A mutation in the variable repeat region of the aggrecan gene (AGC1) causes a form of spondyloepiphyseal dysplasia associated with severe, premature osteoarthritis."

(PMID: 16080123)

[3].

"The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain."

(PMID: 1569188)

[4].

"Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry."

(PMID: 21998595)

[5].

"A missense mutation in the aggrecan C-type lectin domain disrupts extracellular matrix interactions and causes dominant familial osteochondritis dissecans."

(PMID: 20137779)

[6].

"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

(PMID: 20379614)

[7].

"The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature."

(PMID: 20546612)

[8].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[9].

"Variable number of tandem repeat polymorphisms (VNTRs) in the ACAN gene associated with pectus excavatum."

(PMID: 21039430)

[10].

"Association between the expression of aggrecan and the distribution of aggrecan gene variable number of tandem repeats with symptomatic lumbar disc herniation in Chinese Han of Northern China."

(PMID: 20505571)

[1].

人Aggrecan核心蛋白(ACAN)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人Aggrecan核心蛋白(ACAN)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人Aggrecan核心蛋白(ACAN)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人Aggrecan核心蛋白(ACAN)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人Aggrecan核心蛋白(ACAN)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人Aggrecan核心蛋白(ACAN)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人Aggrecan核心蛋白(ACAN)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人Aggrecan核心蛋白(ACAN)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

反馈墙

评论数 : 0

所有用户