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SLC6A4 (基因名), Sodium-dependent serotonin transporter (蛋白名), sc6a4_human.
产品名称:

Human SLC6A4/ Sodium-dependent serotonin transporter Recombinant Protein
钠依赖性血清素转运体

货号:

R2290h

商标:
EIAab®
监管等级:
别名:

5HT transporter, Solute carrier family 6 member 4, 5HTT, SERT, HTT, SERT

序列号:
P31645
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human SLC6A4 Protein
规格 & 价格: cart
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Human SLC6A4 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 17q11.2 by HGNC 17q11.2 by Entrez Gene 17q11.2 by Ensembl
SLC6A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Monomer or homooligomer (By similarity). Interacts with TGFB1I1. Interacts (via sialylated form) with MYH9. Interacts with SEC23A, SEC24C and PATJ. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake. Interacts with filamentous actin and STX1A (By similarity). Interacts (via C-terminus) with VIM. Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly. Interacts with RAB4 (GTP-bound form); the interaction retains transporter molecules intracellularly.


功能:
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.


亚细胞位置:
Cell membrane Multi-pass membrane protein Endomembrane system Multi-pass membrane protein Endosome membrane Multi-pass membrane protein Could be part of recycling endosomes (PubMed:18227069, PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity). Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858) (PubMed:18227069).


该产品尚未在任何出版物中被引用。

[1].
"Alteration of gastric functions and candidate genes associated with weight reduction in response to sibutramine."

[2].
"Age-dependent antidepressant pharmacogenomics: polymorphisms of the serotonin transporter and G protein beta3 subunit as predictors of response to fluoxetine and nortriptyline."

[3].
"Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients."

[4].
"Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression."

[5].
"Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization."
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