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首页  >  重组蛋白  >  Human SEMA4D Recombinant Protein
SEMA4D (基因名), Semaphorin-4D (蛋白名), sem4d_human.
产品名称:

Human SEMA4D/ Semaphorin-4D Recombinant Protein
脑信号蛋白4D

货号:

R2275h

商标:
EIAab®
监管等级:
别名:

A8, BB18, GR3, CD100, C9orf164, CD100, SEMAJ

序列号:
Q92854
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human SEMA4D Protein
规格 & 价格: cart
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Human SEMA4D Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 9q22.2 by HGNC 9q22.2 by Entrez Gene 9q22.2 by Ensembl
SEMA4D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer. Interacts with PLXNB2 (By similarity). Binds PLXNB1.


功能:
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.


亚细胞位置:
Cell membrane Single-pass type I membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation."

[2].
"Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway."

[3].
"Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates."

[4].
"Candidate gene analysis of semaphorins in patients with Alzheimer's disease."

[5].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[6].
"Structural basis of semaphorin-plexin signalling."

[7].
"The semaphorin 4D-plexin-B signalling complex regulates dendritic and axonal complexity in developing neurons via diverse pathways."

[8].
"Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex."

[9].
"Prognostic significance of CD100 expression in soft tissue sarcoma."

[10].
"CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72."
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