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SLA2 (基因名), Src-like-adapter 2 (蛋白名), slap2_human.
产品名称:

Human SLA2/ Src-like-adapter 2 Recombinant Protein
Src-like-adapter2

货号:

R15263h

商标:
EIAab®
监管等级:
别名:

Modulator of antigen receptor signaling, Src-like adapter protein 2, MARS, SLAP-2, C20orf156, SLAP2

序列号:
Q9H6Q3
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human SLA2 Protein
规格 & 价格: cart
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Human SLA2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 20q11.23 by HGNC 20q11.23 by Entrez Gene 20q11.23 by Ensembl
SLA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts (via SH2 domain) with ZAP70 (phosphorylated) and CD3Z (phosphorylated). Interacts (via SH2 domain) with CSF1R (phosphorylated) (By similarity). Interacts (via its C-terminal domain) with CBL (phosphorylated).


功能:
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.


亚细胞位置:
Isoform 2 Cytoplasm May be cytoplasmic and is not localized to membranes.


该产品尚未在任何出版物中被引用。

[1].
"Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling."

[2].
"Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v."

[3].
"A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling."

[4].
"The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease."

[5].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[7].
"Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling."

[8].
"The DNA sequence and comparative analysis of human chromosome 20."

[9].
"In silico prediction of physical protein interactions and characterization of interactome orphans."

[10].
"The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells."
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