首页 > 重组蛋白 > Human SMC4 Recombinant Protein

SMC4 (基因名), Structural maintenance of chromosomes protein 4 (蛋白名), smc4_human.

产品名称:

Human SMC4/ Structural maintenance of chromosomes protein 4 Recombinant Protein
染色体结构维持蛋白4

货号:

R3349h

商标:

EIAab^®

监管等级:

RUO

别名:

Chromosome-associated polypeptide C, XCAP-C homolog, hCAP-C, SMC protein 4, CAPC, SMC4L1

序列号:

Q9NTJ3

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cancer

规格 & 价格:

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Human SMC4 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 3q25.33 by HGNC 3q25.33 by Entrez Gene 3q25.33 by Ensembl

SMC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Forms a heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.

功能:

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

亚细胞位置:

Nucleus Cytoplasm Chromosome In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

数据库链接

UniGene:

Hs.58992

SMR:

Q9NTJ3

STRING:

9606.ENSP00000341382

KEGG:

hsa:10051

MIM:

605575

Pfam:

PF06470

Uniprot:

Q9NTJ3

相关产品

Mouse Smc4 ELISA Kit

Mouse Smc4 CLIA Kit

Mouse Smc4 Protein

Mouse Smc4 Polyclonal Antibody

Mouse Smc4 Monoclonal Antibody

序列长度:

1288

序列:

仅供参考，详细请咨询（services@eiaab.com）

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1288:

LRNNMFEISD | RLIGIYKTYN | ITKSVAVNPK | EIASKGLC

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics."

(PMID: 9789013)

[2].

"A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation."

(PMID: 10958694)

[3].

"Isolation and characterization of a human cDNA homologous to the Xenopus laevis XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family."

(PMID: 10319587)

[4].

"Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study."

(PMID: 20800603)

[5].

"Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma."

(PMID: 17488335)

[1].

人染色体结构维持蛋白4(SMC4)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人染色体结构维持蛋白4(SMC4)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人染色体结构维持蛋白4(SMC4)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人染色体结构维持蛋白4(SMC4)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人染色体结构维持蛋白4(SMC4)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人染色体结构维持蛋白4(SMC4)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人染色体结构维持蛋白4(SMC4)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人染色体结构维持蛋白4(SMC4)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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