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SMO (基因名), Smoothened homolog (蛋白名), smo_human.
产品名称:

Human SMO/ Smoothened homolog Recombinant Protein
平滑同源物

货号:

R15161h

商标:
EIAab®
监管等级:
别名:

Protein Gx, SMO, SMOH

序列号:
Q99835
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Development Biology
Human SMO Protein
规格 & 价格: cart
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Human SMO Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 7q32.1 by HGNC 7q32.1 by Entrez Gene 7q32.1 by Ensembl
SMO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer. Interacts with ARRB2. Interacts with KIF7. Interacts with BBS5 and BBS7; the interactions are indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO.


功能:
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.


亚细胞位置:
Membrane Multi-pass membrane protein Cell projection Cilium


该产品尚未在任何出版物中被引用。

[1].
"A Recurrent Mosaic Mutation in SMO, Encoding the Hedgehog Signal Transducer Smoothened, Is the Major Cause of Curry-Jones Syndrome."

[2].
"Identification of recurrent SMO and BRAF mutations in ameloblastomas."

[3].
"Structure of the human smoothened receptor bound to an antitumour agent."

[4].
"Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling."

[5].
"Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts."

[6].
"MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer."

[7].
"High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility."

[8].
"Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk."

[9].
"Genetic mutations associated with cigarette smoking in pancreatic cancer."

[10].
"High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men."
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