首页 > 重组蛋白 > Human SSTR2 Recombinant Protein

SSTR2 (基因名), Somatostatin receptor type 2 (蛋白名), ssr2_human.

产品名称:

Human SSTR2/ Somatostatin receptor type 2 Recombinant Protein
生长抑素2型受体

货号:

R2292h

商标:

EIAab^®

监管等级:

RUO

别名:

SRIF-1, SS-2-R

序列号:

P30874

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human SSTR2 Protein

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产品说明书

说明书:

MSDS:

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数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 17q25.1 by HGNC 17q25.1 by Entrez Gene 17q25.1 by Ensembl

SSTR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).

功能:

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

亚细胞位置:

Cell membrane Multi-pass membrane protein Cytoplasm Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.

数据库链接

UniGene:

Hs.514451

SMR:

P30874

STRING:

9606.ENSP00000350198

KEGG:

hsa:6752

MIM:

182452

Pfam:

PF00001

Uniprot:

P30874

相关产品

Mouse Sstr2 ELISA Kit

Rat Sstr2 ELISA Kit

Bovine SSTR2 ELISA Kit

Pig SSTR2 ELISA Kit

Dog SSTR2 ELISA Kit

序列长度:

369

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

350:

369:

NETTETQRTL | LNGDLQTSI

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Association of SSTR2 polymorphisms and glucose homeostasis phenotypes: the Insulin Resistance Atherosclerosis Family Study."

(PMID: 19324939)

[2].

"Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization."

(PMID: 18653781)

[3].

"Analysis of somatostatin receptors 2 and 5 polymorphisms in patients with acromegaly."

(PMID: 15914528)

[4].

"Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation."

(PMID: 8386508)

[5].

"Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney."

(PMID: 1346068)

[6].

"Identification of critical residues involved in ligand binding and G protein signaling in human somatostatin receptor subtype 2."

(PMID: 22495673)

[7].

"SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells."

(PMID: 22932785)

[8].

"Somatostatin receptor 2 expression determined by immunohistochemistry in cold thyroid nodules exceeds that of hot thyroid nodules, papillary thyroid carcinoma, and Graves' disease."

(PMID: 20450431)

[9].

"A Large-scale genetic association study of esophageal adenocarcinoma risk."

(PMID: 20453000)

[10].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[1].

人生长抑素2型受体(SSTR2)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人生长抑素2型受体(SSTR2)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人生长抑素2型受体(SSTR2)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人生长抑素2型受体(SSTR2)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人生长抑素2型受体(SSTR2)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人生长抑素2型受体(SSTR2)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人生长抑素2型受体(SSTR2)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人生长抑素2型受体(SSTR2)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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