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STAT5A (基因名), Signal transducer and activator of transcription 5A (蛋白名), sta5a_human.
产品名称:

Human STAT5A/ Signal transducer and activator of transcription 5A Recombinant Protein
信号传导和转录激活因子5

货号:

R1738h

商标:
EIAab®
监管等级:
别名:

STAT5

序列号:
P42229
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human STAT5A Protein
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Human STAT5A Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 17q21.2 by HGNC 17q21.2 by Entrez Gene 17q21.2 by Ensembl
STAT5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7. Interacts with ERBB4.


功能:
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.


亚细胞位置:
Cytoplasm Nucleus Translocated into the nucleus in response to phosphorylation.


该产品尚未在任何出版物中被引用。

[1].
"NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain."

[2].
"Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells."

[3].
"Identification and purification of human Stat proteins activated in response to interleukin-2."

[4].
"A polymorphism associated with STAT3 expression and response of chronic myeloid leukemia to interferon α."

[5].
"Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo."

[6].
"Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus."

[7].
"Risk of meningioma and common variation in genes related to innate immunity."

[8].
"Polymorphisms in innate immunity genes and risk of childhood leukemia."

[9].
"Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls."

[10].
"Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia."
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