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TAB2 (基因名), TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (蛋白名), tab2_human.
产品名称:

Human TAB2/ TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 Recombinant Protein
磷酸化转化生长因子β活化激酶结合蛋白2

货号:

R2882h

商标:
EIAab®
监管等级:
别名:

Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, TGF-beta-activated kinase 1-binding protein 2, TAB-2, KIAA0733, MAP3K7IP2

序列号:
Q9NYJ8
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human TAB2 Protein
规格 & 价格: cart
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Human TAB2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 6q25.1 by HGNC 6q25.1 by Entrez Gene 6q25.1 by Ensembl
TAB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1. Interacts with TRIM5.


功能:
Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.


亚细胞位置:
Membrane Peripheral membrane protein Cytoplasm Cytosol Following IL1 stimulation, translocation occurs from the membrane to cytosol.


该产品尚未在任何出版物中被引用。

[1].
"TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway."

[2].
"Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain."

[3].
"RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation."

[4].
"Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling."

[5].
"TAK1 is a ubiquitin-dependent kinase of MKK and IKK."
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