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TAB3 (基因名), TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (蛋白名), tab3_human.
产品名称:

Human TAB3/ TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 Recombinant Protein
磷酸化转化生长因子β活化激酶结合蛋白3

货号:

R2881h

商标:
EIAab®
监管等级:
别名:

Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, TGF-beta-activated kinase 1-binding protein 3, TAB-3, MAP3K7IP3

序列号:
Q8N5C8
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human TAB3 Protein
规格 & 价格: cart
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Human TAB3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: Xp21.2 by HGNC Xp21.2 by Entrez Gene Xp21.2 by Ensembl
TAB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3) appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may act in a cooperative manner with TAB3. Interacts with WDR34 (via the WD domains). Interacts with RBCK1. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with TRIM5.


功能:
Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.


亚细胞位置:
N/A


该产品尚未在任何出版物中被引用。

[1].
"TAB3, a new binding partner of the protein kinase TAK1."

[2].
"Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling."

[3].
"Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex."

[4].
"RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation."

[5].
"Identification of a human NF-kappaB-activating protein, TAB3."
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