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AXL (基因名), Tyrosine-protein kinase receptor UFO (蛋白名), ufo_human.
产品名称:

Human AXL/ Tyrosine-protein kinase receptor UFO Recombinant Protein
酪氨酸蛋白激酶受体不明飞行物

货号:

R2483h

商标:
EIAab®
监管等级:
别名:

AXL oncogene, UFO

序列号:
P30530
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human AXL Protein
规格 & 价格: cart
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Human AXL Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 19q13.2 by HGNC 19q13.2 by Entrez Gene 19q13.2 by Ensembl
AXL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Heterodimer and heterotetramer with ligand GAS6. Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2, PIK3R3, PLCG1, SOCS1 and TNS2. Part of a complex including AXL, TNK2 and GRB2, in which GRB2 promotes AXL recruitment by TNK2.


功能:
(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:22156524, PubMed:22673088, PubMed:25277499, PubMed:21501828). Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:17005688).


亚细胞位置:
Cell membrane Single-pass type I membrane protein


该产品尚未在任何出版物中被引用。

[1].
"axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase."

[2].
"The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development."

[3].
"Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling."

[4].
"Structural basis for Gas6-Axl signalling."

[5].
"Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation."

[6].
"Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor."

[7].
"Acidification prevents endothelial cell apoptosis by Axl activation."

[8].
"Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin."

[9].
"Expression of receptor-type tyrosine kinase, Axl, and its ligand, Gas6, in pediatric thyroid carcinomas around chernobyl."

[10].
"Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl."
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