Rat Ahr/ Aryl hydrocarbon receptor CLIA Kit
芳烃受体

货号:

U1354r

商标:

EIAab^®

监管等级:

RUO

别名:

Ah receptor

检测方法:

CLIA

特异性:

Natural and recombinant rat Aryl hydrocarbon receptor

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Rat Ahr CLIA Kit

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通用注释

亚单元:

Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with MYBBP1A, NEDD8 and IVNS1ABP. Interacts with ARNTL/BMAL1 (By similarity). Interacts with HSP90AB1.

功能:

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.

亚细胞位置:

Cytoplasm Nucleus Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.

数据库链接

UniGene:

Rn.91370

SMR:

P41738

STRING:

10116.ENSRNOP00000006618

Pfam:

PF00010

Uniprot: