ADAM17 (基因名), Disintegrin and metalloproteinase domain-containing protein 17 (蛋白名), ada17_human.
产品名称:
ADAM17 Antibody
解整合素和金属蛋白酶结构域蛋白17
货号:
M1319Rb-h
商标:
EIAab®
监管等级:
别名:
Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b, ADAM 17, CSVP, TACE
反应性:
human
免疫原:
corresponding to a sequence mapping at the Recombinant Protein of P78536
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Monoclonal
亚型:
Mouse IgG
应用:
推荐产品:
研究领域:
Neurosciences
R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释
亚单元:
Interacts with MAD2L1, MAPK14 and MUC1.
功能:
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
亚细胞位置:
Membrane
Single-pass type I membrane protein
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