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IL6ST (基因名), Interleukin-6 receptor subunit beta (蛋白名), il6rb_human.
产品名称:

IL6ST Antibody

货号:

P0046Rb-h

商标:
EIAab®
监管等级:
别名:

CDw130, Interleukin-6 signal transducer, Membrane glycoprotein 130, Oncostatin-M receptor subunit alpha, gp130, CD130, IL-6 receptor subunit beta

序列号:
P40189
反应性:
human
免疫原:
Recombinant human IL6ST protein ( R0046h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Cancer
Human IL6ST Polyclonal Antibody
规格 & 价格: cart
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Human IL6ST Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemical analysis of paraffin-embedded using IL6ST antibody at 1:500 dilution.
通用注释


亚单元:
Component of a hexamer of two molecules each of IL6, IL6R and IL6ST (PubMed:12829785). Forms heterodimers composed of LIFR and IL6ST (type I OSM receptor) which are activated by LIF and OSM (PubMed:8999038). Also forms heterodimers composed of OSMR and IL6ST (type II receptor) which are activated by OSM but not by LIF (PubMed:8999038). Homodimer. The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6 (PubMed:11238858, PubMed:11251120). Interacts with HCK (PubMed:9406996). Interacts with INPP5D/SHIP1.


功能:
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition.


亚细胞位置:
Isoform 2 Secreted


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