CD14 (基因名), Monocyte differentiation antigen CD14 (蛋白名), cd14_human.
产品名称:
Human CD14/ Monocyte differentiation antigen CD14 CLIA Kit
单核细胞分化抗原CD14
货号:
U0685h
商标:
EIAab®
监管等级:
别名:
Myeloid cell-specific leucine-rich glycoprotein, CD14
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
31.2-2000pg/mL
特异性:
Natural and recombinant human Monocyte differentiation antigen CD14
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Immunology
通用注释
亚单元:
Interacts with LPS-bound LPB (PubMed:1698311, PubMed:23264655). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Interacts with LPAR1 (By similarity). Interacts with the TLR2:TLR6 or TLR2:TLR1 heterodimers; upon interaction with ligands such as diacylated lipopeptides and triacylated lipopeptides, respectively (PubMed:16880211). Interacts with MYO18A (PubMed:25965346).
功能:
Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).
亚细胞位置:
Cell membrane
Lipid-anchor
GPI-anchor
Secreted
Membrane raft
Golgi apparatus
Secreted forms may arise by cleavage of the GPI anchor.
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