Rat Cd14/ Monocyte differentiation antigen CD14 CLIA Kit
单核细胞分化抗原CD14

货号:

U0685r

商标:

EIAab^®

监管等级:

RUO

别名:

Myeloid cell-specific leucine-rich glycoprotein, CD14

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant rat Monocyte differentiation antigen CD14

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Immunology

规格 & 价格:

关注

Rat Cd14 CLIA Kit

邮箱 *

消息 *

Please 登录.

产品说明书

说明书:

MSDS:

在线询价

数据
文献
序列 / 3D
反馈墙 (0)

通用注释

亚单元:

Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPS-bound LPB. Interacts with LPAR1. Interacts with the TLR2:TLR6 or TLR2:TLR1 heterodimers; upon interaction with ligands such as diacylated lipopeptides and triacylated lipopeptides, respectively. Interacts with MYO18A.

功能:

Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).

亚细胞位置:

Cell membrane Lipid-anchor GPI-anchor Secreted Membrane raft Golgi apparatus Soluble, secreted forms seem to exist. They may arise by cleavage of the GPI anchor.

数据库链接

UniGene:

Rn.42942

SMR:

Q63691

STRING:

10116.ENSRNOP00000023977

KEGG:

rno:60350

Pfam:

PF13516

Uniprot: