HCAR2 (基因名), Hydroxycarboxylic acid receptor 2 (蛋白名), hcar2_human.
产品名称:
Human HCAR2/ Hydroxycarboxylic acid receptor 2 CLIA Kit
货号:
U16030h
商标:
EIAab®
监管等级:
别名:
G-protein coupled receptor 109A, G-protein coupled receptor HM74A, Niacin receptor 1, Nicotinic acid receptor, GPR109A, HCA2, HM74A, NIACR1
检测方法:
CLIA
特异性:
Natural and recombinant human Hydroxycarboxylic acid receptor 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
N/A
功能:
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
数据库链接
UniGene:
STRING:
KEGG:
MIM:
Pfam:
Uniprot:
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