Rat Hcar2/ Hydroxycarboxylic acid receptor 2 CLIA Kit

货号:

U16030r

商标:

EIAab^®

监管等级:

RUO

别名:

G-protein coupled receptor 109, G-protein coupled receptor 109A, G-protein coupled receptor HM74, Niacin receptor 1, Nicotinic acid receptor, Protein PUMA-G, Gpr109, Gpr109a, Gpr109b, Niacr1, Pumag

检测方法:

CLIA

特异性:

Natural and recombinant rat Hydroxycarboxylic acid receptor 2

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Rat Hcar2 CLIA Kit

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通用注释

亚单元:

N/A

功能:

Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.

亚细胞位置:

Cell membrane Multi-pass membrane protein

数据库链接

UniGene:

Rn.214478

STRING:

10116.ENSRNOP00000036057

KEGG:

rno:353250

Pfam:

PF00001

Uniprot: