Human HDAC10/ Polyamine deacetylase HDAC10 CLIA Kit

货号:

U11381h

商标:

EIAab^®

监管等级:

RUO

别名:

Histone deacetylase 10, HD10

检测方法:

CLIA

特异性:

Natural and recombinant human Polyamine deacetylase HDAC10

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Human HDAC10 CLIA Kit

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通用注释

亚单元:

Interacts with HDAC3 (PubMed:11861901). Interacts with HDAC2 and NCOR2/SMRT (PubMed:11739383). Interacts with HSPA8/HSC70 (PubMed:23801752). Interacts with MSH2 (PubMed:26221039).

功能:

Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039).

亚细胞位置:

Cytoplasm Nucleus Excluded from nucleoli.

数据库链接

UniGene:

Hs.26593

SMR:

Q969S8

STRING:

9606.ENSP00000216271

KEGG:

hsa:83933

MIM: